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P-MAPA immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting TLR4 signaling
(2018-01-17)
Background: Toll-like receptors (TLRs) are transmembrane proteins expressed on the surface of ovarian cancer (OC) and immune cells. Identifying the specific roles of the TLR-mediated signaling pathways in OC cells is ...
Utilização diferencial dos TLR2 e TLR9 pelas células do eixo fagocítico mononuclear durante a infecção aguda por T. cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2015-02-09)
This work highlights the differential use of TLRs by innate immune cells as a central mechanism in the organization of the response against the T. cruzi, the etiological agent of Chagas disease. To this, we had used flow ...
The role of Toll-like receptor 4 signaling pathway in ovarian, cervical, and endometrial cancers
(2020-04-15)
Toll-like receptors (TLRs) are critical sensors related to inflammation and tumorigenesis. Among all subtypes, the TLR4 is a highly described transmembrane protein involved in the inflammatory process. The TLR4/myeloid ...
RANKL expression is differentially modulated by TLR2 and TLR4 signaling in fibroblasts and osteoblasts
(2014)
Resident, non-immune cells express various pattern-recognition receptors and produce inflammatory cytokines in response to microbial antigens, during the innate immune response. Alveolar bone resorption is the hallmark of ...
Papel dos receptores do tipo Toll endossomais na resistência à infecção por Toxoplasma gondii
(Universidade Federal de Minas GeraisUFMG, 2013-03-01)
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum apicomplexa and can virtually infect all warm-blood vertebrates. Although humans are considered accidental intermediate hosts, one third of ...
Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
(American Association of Immunologists, 2013)
Variability of the dendritic cell response triggered by different serotypes of Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis is toll-like receptor 2 (TLR2) or TLR4 dependent
(American Academy of Periodontology, 2015)
Background: Different serotypes of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis have been shown to induce differential dendritic cell (DC) responses. This study investigates whether cytokine and ...
Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer
(Biomed Central Ltd, 2015-02-06)
Background: Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) acts ...
Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice
(Springer, 2012-07-01)
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains ...